SCIENCE & Results

Results That Scale

25+ successful projects in more than 10 different organisms = Broad host compatibility.

15+

Years of Research

25+

Successful Projects

200+

Peer-Reviewed Publications

Patent Families

Discover how MNDL Bio’s AI engine is transforming protein production across the globe.

Small Protein in E. coli Cell-Free System

Objective: Increase the expression of a nanobody (~15kDa) within a bacterial cell-free system.
The Challenge: The original DNA sequence was highly inefficient, resulting in very low protein expression levels.
The Result: By utilizing MNDL Bio-designed sequence variants, the team achieved a significant breakthrough, improving expression levels by 9.5 to 15-fold.

Biosensor Development in E. coli

Objective: Enhance the development of a biosensor by significantly increasing the expression of its reporter gene.
The Challenge: A previous version of the biosensor was not viable for practical field applications because of its low signal-to-noise ratio.
The Result: Through the design and testing of 370 unique promoter variants, MNDL Bio achieved up to a ~10x increase in reporter activity, making the sensor field-ready.

Engineered Enzyme in E. coli

Objective: Increase the expression levels of a custom-engineered enzyme within an E. coli host.
The Challenge: Initial attempts at production were unsuccessful, as the engineered enzyme yield failed to meet the necessary expression goals for commercial viability.
The Result: After screening 10 specialized MNDL Bio variants, one was identified that provided a ~2.5-fold increase in expression, meeting the project's target.

Translation Optimization in Plants

Objective: Improve the production of a complex protein using the Nicotiana tabacum (tobacco) plant as a host.
The Challenge: Although the product was already on the market and showed high mRNA levels, the majority of the proteins produced were not biologically active.
The Result: MNDL Bio optimized the gene specifically to improve co-translational protein folding, leading to a 3x improvement in the yield of active, functional protein.