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Adapting Gene Expression to any Organism with ChimeraUGEM
ChimeraUGEM: unsupervised gene expression modeling in any given organism Motivation Regulation of the amount of protein that is...
Jul 8, 2024
Algorithms for ribosome traffic engineering and their potential in improving host cells’ titer and growth rate | nature.com
mRNA translation is a fundamental cellular process consuming most of the intracellular energy; thus, it is under extensive evolutionary...
Jul 8, 2024
Quantitative Modeling of Ribosomal Small Subunit Dynamics Using TCP-seq data
Modeling the ribosomal small subunit dynamic in s. cerevisiae based on TCP-seq data Translation Complex Profile Sequencing (TCP-seq), a...
Jul 8, 2024
Unsupervised Learning for Heterologous Gene Expression Optimization Based on Host Genomic Context
Motivation: Dozens of studies in recent years have demonstrated that codon usage encodes various aspects related to all stages of gene...
Jul 8, 2024
High-resolution modeling of the selection on local mRNA folding strength in coding sequences across the tree of life
mRNA can form local secondary structure within the protein-coding sequence, and the strength of this structure is thought to influence...
Jul 8, 2024
Research Powering Our Solutions
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