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AI-Powered DNA Engineering
for Scalable Protein Production

Smarter design for higher expression and reliable scale-up

THE CHALLENGE

​80% of recombinant protein expression programs fail to express at meaningful levels or scale efficiently.

THE SOLUTION

Increase your chances of success with MNDL Bio’s host-optimized DNA sequence engineering.
Reduce R&D timelines and costs by moving from trial & error experimentation to predictive, data-driven, in-silico design.

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THE IMPACT
Achieve up to 30× higher protein yields with MNDL Bio’s AI-driven DNA engineering.*

*Results depend on protein, host, and production context.

What MNDL Bio Delivers

MNDL Bio provides host-optimized DNA sequences designed to improve yield, genetic stability, and other critical production metrics, while preserving the original protein amino-acid sequence.

Whole-construct DNA engineering
for expression success and scale

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Broad Host Compatibility

Validated across major expression systems. New host organisms can be supported in silico in under 48 hours.

Synthesis-Ready

Output DNA sequences are validated and instantly ready for synthesis.

Secure & Confidential

Proprietary DNA sequences & project data remain protected & fully under your control.

OUR TECHNOLOGY

A FUSION OF PHYSICS & AI

Proprietary biophysical models, developed and validated over more than 15 years, guide machine learning to enable reliable gene expression design, even in data-limited search spaces.

Improved Yields.
Lower Costs.

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1.5x-30x 

Higher Yields

DNA Double Helix

±1 Year

Faster Time To Market

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50-90%

Lower COGS

TESTIMONIALS

WHAT PEOPLE SAY 

MNDL Bio helped us improve the expression of our industrial enzyme for food applications in a microbial expression system. We achieved a clear increase in expression levels, reached efficiently and with strong technical support throughout the process. A productive and reliable collaboration.

Ziv Zwighaft

CEO, Ambrosia Bio

Working with MNDL Bio exceeded our expectations. Their optimization of our recombinant protein resulted in remarkable gains - a 10× improvement in cell-free expression and a 1.5× boost in bacterial system. The process was fast, data-driven, and their team highly responsive.

Arnon Heyman

CEO, IBI Ag

Partnering with Prof. Tuller's expertise proved invaluable. His algorithms significantly enhanced our design of gene expression in microalgae, enabling us to achieve a substantial increase in biofuel production - a critical benchmark for our success.

Prof. Iftach Yacoby

Molecular Biology Ecology of Plants (Tel Aviv University)

Inefficient, costly gene expression optimization is a fundamental bottleneck in bioproduction today. MNDL Bio's data-driven approach, powered by Tamir Tuller's algorithms, promises a standardized, predictable solution with significant industry impact.

Dr. Or Rotem

Synbio Expert
 

Professor Tamir Tuller has groundbreaking research in the field of computational system biology and synthetic biology, generating advanced computational models that will be exploited and further developed by the MNDL Bio team. We are expecting the team to accelerate timelines and increase yields in bioproduction / biotechnological applications, improving operations and driving innovation in the synthetic biology sector.

Dr. Orly Savyon
CEO, Alagene

join our mission

Ready to improve your recombinant protein expression?

Let’s discuss your project.

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